Tag: biochemistry

Molecules of Emotion

I first came across Pert’s work due to a fairly throwaway reference in Tom Myers’ manual of movement anatomy, Anatomy Trains. As the biological basis of emotion has long interested me, but I have not previously found anything of real value on the subject, and, undeterred by some negative reviews on Amazon (though overall it is well rated), I decided to take a look.

My first surprise was that the book had been written in 1997! That it took me fifteen years even to hear about it, despite an interest in the subject, is astonishing. That the original research goes back to the 1970’s is even more so.

The book has been criticized as too autobiographical with not enough hard science take-aways. It is true that it is autobiographical, and doubtless I also hoped to understand more of the subject at the end of it than I do, though I did learn quite a bit. However, it is also very well written and, except for the last couple of chapters which disappoint, as hard to put down as a good detective novel. So the entertainment value and the broader insight into how the neuropharmacological research community works more than compensated for this failing, and in fact I do not know if there was, at the time of writing, more to be said on the subject than is contained in the book. I do have a couple of more recent books on similar subjects lined up for reading, so check this space.

Where I would fault the book, however, is its tendancy to wild generalization, containing as it does a wide range of claims about body-mind interactions with no effort to discriminate between them. As such, it is more suggestive than authoritative. Certainly, Pert’s work lends weight to the validity claims of many non-pharmacological therapies. A picture emerges from the book as to why these therapies may be successful, and I have no doubt that broadly she is on the right lines. However, there are so many gaps in explaining how these bodymind linkages work that there is really nothing in the book that counts as an explanation. The only things on which she sheds real light are the action of psychedelics and a treatment for AIDS based on blocking the CCR5 receptor, used by the virus, with a molecule based on an endogenous ligand, which still today is struggling to gain official acceptance. The view that the brain is not merely a neurological but also an endocrine organ is doubtless, by now at least, well established, but even the links she shows between emotions and the immune system, which are persuasive at the conceptual level, are difficult to disentangle. Lastly, Pert’s meanderings into alternative and new age therapies tend more to discredit than buttress her thesis – and I say this as someone with plenty of sympathy for some of these therapies.

I did take from the book a real sense of the biochemical unity of life. It is extraordinary that the “molecules of emotion” are so widely distributed in nature, with analogues even in plants. Plus she quotes approvingly Reich and Lowen, which is courageous enough, though whether her research actually provides support for the idea of somatically stored emotions is not clear.

Although it is not intended, and does not function, as a textbook, Pert is a relatively unknown but important scientific pioneer and her work deserves to be read for this reason as well as for its broader sociological interest.

Somatic climatology

In a previous post, I discussed John Sarno’s ideas on the psychological etiology of pain and other pathologies. In this context I would like to add some further hypotheses on how emotional repression affects the body and the felt sense.

The repression of emotions from consciousness does not merely prevent their expression in the neocortex. Emotions are naturally linked to the much more ancient endocrine system, which affects the body by means of hormones produced in the glands and vectored through the bloodstream and ultimately the extracellular matrix. The nervous and endocrine systems are interdependent, with response coordinated by the hypothalamus in the brain. The repression of emotions is a process which affects both the nervous system and certain key endocrine functions related to the evolutionarily adaptive response to the emotion in question. However, the body’s natural response to these locked emotions is not altogether disabled – they continue to produce effects in parts of the somatic and autonomic nervous systems as well as in parts of the endocrine system. The key point to understand is therefore that repression from consciousness is not equivalent to complete somatic disactivation. Repression by the ego is an imperfect dam, around which the stored emotions must find routes in order to maintain homeostasis. Because these routes do not provide for a full discharge of the emotions, however, the body is under constant tension.

We may consider that the primary emotional response is the alloplastic one – the one which is directed to changing the situation at the origin of the emotions being felt – and that it is this alloplastic response which is suppressed (if we are anything like our bonobo cousins, the repressed instinct may frequently be to have sex; this response does not change the external situation as such but rather its social expression, and could be termed mesoplastic or socioplastic). In its place, an autoplastic response is favored – the organism tries to change itself.

The inappropriate and sustained nervous and endocrine response to repressed emotions is what gives rise to the pathologies discussed, and it is important to realize that this is not just a “trick of the mind” but rather that it takes place on a biochemical level which, while not fully autonomous, enjoys a degree of autonomy from the conscious functions which we tend to think of when we use the term “mind”. In reality, of course, it is our terminology and its intrinsic duality which is at fault, because the bodymind operates as an integrated system in which certain material may be withheld from consciousness, but the vast majority is unavailable to consciousness in the first place.

The same objection has to be raised in respect of a focus on pathological syndromes only. In fact, the repressed response does not produce candidate pathologies only, but directly influences the biochemical environment of the body, proprioception, and our mental somatic map. It is not only pain, allergy or disturbed bowel function which may be provoked by emotional circumstances, but more generally also our level of somatic energy, our self-perception and our sense of wellness: aspects which we may think of as an innate part of our personality, but in reality are no more so than these other more obvious disturbances.

This raises, from my perspective, the interesting question of how an undisturbed individual would experience the body and embodiment. If it was not immediately obvious to me that my pain had emotional causes, it was even less obvious that the same was true for my general sense of self, for my general sense of inhabiting the body I inhabit. If this experience can also be altered by an awareness of its etiology, then interesting times lie ahead.

I wish all my readers a happy 2013!

John Sarno’s work on the etiology and treatment of psychosomatic disorders

I have been troubled all my adult life by disorders termed, which generally meant dismissed as, psychosomatic. These are disorders for which no physical etiology can be found, although they may have observable physical manifestations. From a psychological point of view, they have also recently been classified as somatoform disorders. As such, I was very interested to discover recently John Sarno‘s work on the subject.

Sarno’s basic premise is that just as emotional conflict can give rise to neuroses, so it also can give rise to pain and other physical conditions. This linkage may be direct, with Sarno positing that localized pain is a result of ischemia ordered by the central nervous system. Such emotional conflicts may also, via mechanisms which are presumably diverse, but which Sarno does not elucidate, result in afflictions to which non-psychological factors also contribute, whether in terms of their etiology or their clinical development. A key feature of Sarno’s posited diagnosis of tension myositis syndrome (TMS) is the variability in its lifetime expression. As such, it is an umbrella diagnosis or metadiagnosis for a variety of syndromes which have in common a non-progressive character. For a fuller discussion, read his 2006 book The Divided Mind.

I suffered in my early teens from clinical depression and situational urinary incontinence. By my mid-teens, this was replaced by muscular fasciculations, which I was convinced for a long time had to be a manifestation of a degenerative condition. Muscular function remained mechanically and electrically normal however, and much later this was officially classified as “benign fasciculation syndrome” (although it has receded, I am not fully free of it to this day). I went on at college to develop chronic fatigue syndrome, which at one point resulted in my being almost unable to walk. I also suffered at that time from migraines and back pain, and peri-orbital migraine was a regular occurrence for many years afterwards. During all this time, there have been no notable biochemical abnormalities observed.

Now I have not been monitoring bodily symptoms against my emotional state for many years and so I cannot provide a full account; it has changed immensely for the better, but I have still had my share of annoying things, in particular abdominal pains, and six or seven years ago Achilles tendinitis. Around May last year I developed plantar fasciitis on the left foot; it took a year to heel but then almost immediately the right foot developed the same symptoms. It has been quite debilitating as strenuous effort has tended to worsen it. All this led me to seek effective relief from the pain in various ways, a subject to which I will return.

Sarno’s notion, therefore, is very appealing. Indeed, given the importance of physical complaints, so called “hysterical conversion“, in the early development of psychoanalysis, it is not quite clear why attention has mostly been subsequently restricted to behavioral neuroses, especially outside of the Reichian tradition. Even if the mechanisms remain obscure, it is attractive to view psychosomatic disorders as somatic forms or expressions of neurosis.

However, I suspect the brain is less involved in mediating this relationship than we think. Sarno claims that the pain is directly generated by the brain as a diversion from unwanted emotions which threaten to break through into consciousness. I fancy this is otherwise: the brain is involved, certainly, in the repression of emotions, and by preventing their expression it prevents their discharge. The bodily symptoms, however, do not necessarily require neurological involvement and may arise on the basis of pure biochemistry. This is illustrated by research on the role of myofibroblasts in the mechanic regulation of connective tissue (see here). To me, the idea that the brain is busy, like some cranky old Wizard of Oz, devising ways to present consciousness with ever-new diversions seems crude, and it is not required to explain Sarno’s clinical outcomes. Variation in the site of pain may have simple biomechanical explanations.

So Sarno’s work is pathbreaking and liberating, definitively contributing to a shift in understanding of psychosomatic disorders, but it nonetheless needs to be taken with the necessary pinch of salt. Sarno offers, in The Divided Mind, no epidemiological data to back up his claim that the syndrome chosen by the brain is a matter of fashion (in a Kuhnian perspective, it is of course much more plausible that it is the diagnosis and corresponding collection of statistics which is driven by fashion, rather than the patient’s symptoms, especially since many of these diagnoses are evidently imprecise). He also offers no evidence to back up the conjecture that local ischemia explains the pain or that this is cerebrally induced (and if so, how). Indeed, the locus of pain is not discussed either, and some statements suggest Sarno does not have a deep understanding of myofascial biochemistry.

Sarno follows the usual path of airbrushing Reich out of the history of psychoanalysis, although it should be obvious that Reich was the first to look at the body and mind as a whole. However, his major error is to follow Freud’s mistrust of the id and misplaced trust in the superego. Freud, as we know, viewed repression as in many ways akin to a virtue upon which civilization depended. Sarno also paints a picture of the “childish, primitive” unconscious as the enemy within, even referring to it, with patent ideological bias, as the “dregs of evolution”, contrasting it to the “ethical and moral” conscious mind, a view hardly conducive to integration and well-being, and one which even Freud would have struggled to maintain (Nietzsche of course having demolished it comprehensively). His negative views of the moral quality of children are particularly depressing in their Calvinist overtones.

Several of Sarno’s statements in relation to brain neurology seem completely wrong: for example he attributes “rational, civilized” behavior to the neocortex, labeling it “that part of the human brain that has been added in the process of evolution”, even though the neocortex developed in the first mammals. The attempted equation between brain structures and Freud’s threefold division of the mind is presented as fact, whereas it is not a notion entertained by any mainstream psychoanalyst or neurologist. Indeed, Sarno oscillates gaily between the unconscious/preconscious/conscious model and the id/ego/superego model as if they were the same thing.

All this aside, this is a book which opened my mind to what now seems like an obvious fact but has long gone unnoticed, namely that the mind does not simply affect the body in vague, unspecified ways but perhaps in very specific ways where a direct link can be drawn between emotional circumstances and pain. It is pretty clear now to me what the circumstances were which led to both episodes of plantar fasciitis, and I am inclined to agree with Sarno that this knowledge is immensely emancipatory.